Cell-permeable protein inhibitors of calpain

摘要

Fusion proteins have been discovered that contain a calpastatin peptide and a signal sequence capable of delivering the fusion protein into a cell. These proteins can be used to inhibit calpain and, more specifically, to inhibit platelet aggregation or degranulation, to inhibit or reverse erythrocyte sickling, to inhibit a human immunodeficiency virus (HIV), or to inhibit unwanted cellular proliferation or migration.