ONCOGENE- OR VIRUS-CONTROLLED EXPRESSION SYSTEMS

摘要

The invention relates to a nucleic acid construct for expressing an effector gene, with the nucleic acid construct containing a promoter I (component a) which controls the expression of a transcription factor gene (component b) which is likewise contained in the nucleic acid construct, and containing a promoter II (component c) to which the gene product of the transcription factor gene binds specifically and which controls the expression of an effector gene (component d) which is likewise contained in the nucleic acid construct, wherein the activity of the gene product of the transcription factor gene depends on one or more cellular regulatory proteins which bind specifically to this gene product and affect its activity, to an isolated cell which contains said nucleic acid construct, to the use of said construct for preparing a drug for treating diseases, to the use of said cell for the same purpose and to a process for preparing the nucleic acid construct.