发明名称 SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS
摘要 Selected substituted pyridine compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein a. o. X is O, S, S(O), S(O)2 or NR2; Y is C(O)-NR3R4 or -NR4-C(O)-R3; R1 is a cycloalkyl, aryl, heterocyclyl or heteroaryl radical which is optionally substituted by 1-4 radicals of alkyl, halo, haloalkyl, cyano, azido, nitro, amidino, R18-Z18- or R18-Z18-alkyl; provided that the total number of aryl, heteroaryl, cycloalkyl and heterocyclyl radicals in R1 is 1-3; and provided when Y is -NR4-C(O)-R3 and X is O or S, R1 is other than a 2-pyrimidinyl radical; R2 is a hydrogen or alkyl radical; R3 is an aryl or heteroaryl radical which is optionally substituted by 1-5 radicals of alkyl, halo, haloalkyl, cyano, azido, nitro, amidino, R19Z19- or R19-Z19-alkyl; provided that the total number of aryl and heteroaryl radicals in R3 is 1-3; and provided when Y is -C(O)- NR3R4, R3 is other than a phenyl or naphthyl having an amino, nitro, cyano, carboxy or alkoxycarbonyl, are effective for prophylaxis and treatment of diseases, such as TNF-.alpha., IL-1.beta., IL-6 and/or IL-8 mediated diseases, and other maladies, such as pain and diabetes. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving inflammation, pain, diabetes, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
申请公布号 CA2307552(A1) 申请公布日期 1999.05.20
申请号 CA19982307552 申请日期 1998.11.04
申请人 AMGEN INC. 发明人 JOSEY, JOHN A.;SCHLACHTER, STEPHEN T.;MANTLO, NATHAN B.
分类号 A61K31/44;A61K31/4418;A61K31/4427;A61K31/443;A61K31/4433;A61K31/4436;A61K31/4439;A61K31/444;A61K31/496;A61P1/04;A61P3/10;A61P3/14;A61P9/02;A61P9/10;A61P11/00;A61P11/06;A61P17/00;A61P17/06;A61P19/02;A61P19/06;A61P19/08;A61P19/10;A61P21/06;A61P25/28;A61P27/02;A61P27/16;A61P29/00;A61P31/12;A61P31/18;A61P35/00;A61P35/02;A61P37/06;A61P37/08;C07D213/73;C07D213/75;C07D213/82;C07D401/12;C07D405/12;C07D409/12;C07D413/12;C07D417/12;C07D471/04;(IPC1-7):C07D213/73 主分类号 A61K31/44
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