SALICYLATE DERIVATIZED THERAPEUTIC AND DIAGNOSTIC AGENTS
摘要
The present invention relates to novel salicylate compounds which comprise a salicylate moiety and a biologically active agent of interest, where the compound binds and bonds specifically through reaction of the salicylate ester to serum albumin at Lys 199. Albumin is a long-lived moiety present in the blood. Novel salicylate compounds of the present invention provide for long-lived maintenance of the biologically active entity in the host. These compounds find broad applications in prophylactic and therapeutic applications, production of antibodies, reduction of the biologically effective concentration or activity of an endogenous or exogenous blood component, and in other situations where long term administration of a physiologically active compound is of interest.
申请公布号
WO9924076(A2)
申请公布日期
1999.05.20
申请号
WO1998US23706
申请日期
1998.11.06
申请人
CONJUCHEM, INC.;KRANTZ, ALEXANDER;SONG, YONG HONG;BRIDON, DOMINIQUE, P.;HARDY, MARGARET;CHEN, QUI QUI;SETTINERI, TINA
发明人
KRANTZ, ALEXANDER;SONG, YONG HONG;BRIDON, DOMINIQUE, P.;HARDY, MARGARET;CHEN, QUI QUI;SETTINERI, TINA