NOVEL IFN RECEPTOR 1 BINDING PROTEINS, DNA ENCODING THEM, AND METHODS OF MODULATING CELLULAR RESPONSE TO INTERFERONS

摘要

Novel proteins IR1B1 and IR1B4 have been isolated which bind to the type I IFN receptor IFNAR1 and function in the cellular response to IFNs. DNA encoding such proteins in either the sense or anti-sense orientation can be administered to either enhance or inhibit the cellular response to IFNs. Antibodies to the proteins can be used for isolation of the new protein or for immunodetection thereof.