| 摘要 |
FIELD: organic chemistry and technology. SUBSTANCE: invention proposes a method of synthesis of 3,4-dihydroxy-5-nitrobenz- -aldehyde which is an important intermediate substance used in synthesis of some pharmaceutically essential compounds exhibiting 5-substituted 3-nitrocatechol structure, for example, entacapon. Method involves an interaction of 3-ethoxy-4-hydroxy-5-nitrobenzaldehyde with a reagent that contains zinc chloride, water and hydrogen chloride and the end product is obtained. Reagents used for synthesis can be recirculated easily. EFFECT: simplified method, decreased cost, high purity of end product. 10 cl, 1 ex
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