PIPERAZINE-CYCLODEXTRIN COMPLEXES

摘要

Piperazine-cyclodextrin complexes composed of compounds represented by general formula (I) or salts thereof and easily water-soluble cyclodextrin derivatives: (wherein Q is aryl, a heterocyclic group, diarylmethyl or aralkyl each of which may be substituted; R is a nitrogeous heterobicyclic group or phenyl which may be substituted; and Z is C1-C3 alkylene, C2-C4 alkenylene, C1-C3 monohydroxyalkylene, carbonyl, C1-C2 alkylene having one carbonyl group at the end of the carbon chain or in the middle thereof, or oxalyl). The complexes are improved in water solubility and stability and lowered in local stimulation, and are useful as remedies for circulatory diseases and brain diseases.