PRODUCTION OF NOVEL BOVINE RESPIRATORY SYNCYTIAL VIRUSES FROM cDNAs

摘要

Disclosed is a synthetic cDNA which codes for an infectious bovine respiratory syncytial virus (BRSV). The cDNA may be derived from a single strain of BRSV, or it may be a chimeric cDNA which is derived from more than one strain of BRSV. The invention also includes vectors and host cells containing the cDNA, methods of producing infectious BRSV using the cDNA, methods of producing attenuated BRSVs and vaccines comprising such attenuated BRSVs.