New 2H-1-pyran-2-one derivatives useful as anticonvulsants and neuroprotectants

摘要

2H-1-pyran-2-one derivatives (I) are new. 2H-1-pyran-2-one derivatives of formula (I) are new. R1 = 2-5C alkyl, 4-6C cycloalkyl, 4-8C cycloalkylalkyl or 3-5C alkoxyalkyl; R2 = 2-(3,4-methylenedioxyphenyl)ethyl or a 2-phenylethenyl group which is substituted in the 3-, 4- and 5-position of the benzene ring by R3, R4 and R5; R3, R5 = ethoxy or methoxy; R4 = 1-5C alkoxy, 3-5C alkenyloxy, 4-6C cycloalkoxy, 4-8C cycloalkylalkoxy or 3-5C alkoxyalkoxy. Independent claims are included for: (1) the preparation of (I); and (2) reactive intermediates of formula (II) and their preparation and intermediates (IIIa). R1' = 3-5C alkyl, 4-6C cycloalkyl, 4-8C cycloalkylalkyl or 3-5C alkoxyalkyl.