发明名称 |
HEPATITIS C INHIBITOR PEPTIDES |
摘要 |
Compound of formula (I) active against the Hepatitis C virus, wherein when Q is CH2, a is 0, b is 0 and B is an amide derivative; or when Q is N-Y wherein Y is H or C1-6 alkyl, then B is an acyl derivative; R6, when present, is C1-6 alkyl substituted with carboxyl; R5, when present, is C1-6 alkyl optionally substituted with carboxyl; when Q is either CH2 or N-Y, then Z is oxo or thioxo; R4 is C1-10alkyl, C3-7 cycloalkyl or C4-10 (alkylcycloalkyl); R3 is C1-10 alkyl optionally substituted with carboxyl, C3-7 cycloalkyl or C4-10 (alkylcycloalkyl); W is a proline derivative; R1' is hydrogen, and R1 is C1-6 alkyl optionnaly substituted with thiol; or R1 is C2-6 alkenyl; or R1' and R1 together form a 3- to 6-membered ring; and A is hydroxy or a pharmaceutically acceptable salt or ester thereof. |
申请公布号 |
WO9907733(A3) |
申请公布日期 |
1999.05.20 |
申请号 |
WO1998CA00765 |
申请日期 |
1998.08.10 |
申请人 |
BOEHRINGER INGELHEIM (CANADA) LTD.;LLINAS-BRUNET, MONTSE;POUPART, MARC-ANDRE;RANCOURT, JEAN;SIMONEAU, BRUNO;TSANTRIZOS, YOULA;WERNIC, DOMINIK |
发明人 |
LLINAS-BRUNET, MONTSE;POUPART, MARC-ANDRE;RANCOURT, JEAN;SIMONEAU, BRUNO;TSANTRIZOS, YOULA;WERNIC, DOMINIK |
分类号 |
A61K38/00;A61K38/21;A61P1/16;A61P31/12;C07K5/078;C07K5/083;C07K5/103;C07K5/107;C07K7/06;C07K7/08;C07K14/18 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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