Synthesis of 6 alpha-functionalized estriol haptens and protein conjugate thereof

摘要

Disclosed are 6 alpha -derivatized estriol compounds which, when conjugated to a protein, are useful in the in vivo preparation of antibodies specific to estriol. When labeled with a detectable label, the estriol derivatives are useful as haptens in a competitive immunoassay for estriol which demonstrate superior sensitivity with respect to estriol specific antibodies.