NUCLEIC ACID ENCODING A NERVOUS TISSUE SODIUM CHANNEL

摘要

A novel nucleic acid sequence encoding for a mammalian voltage-gated, preferably TTX-resistant, sodium channel is isolated. Also disclosed are polypeptide produc ts of recombinant expression of these sequences, expression vectors comprising the DNA sequence, a nd host cells transformed with these expression vectors. Other aspects of this invention are p eptides whose sequences are based on the amino acid sequences deduced from these DNA sequences , antibodies specific for such proteins and peptides, procedures for detection and quantitation of such proteins and nucleic acids related thereto. Another aspect of this inventio n is the use of this voltage-gated, preferably tetrodotoxin-resistant, sodium channel as a therapeuti c target for compounds.