发明名称 |
NEUROPEPTIDES ORIGINATING IN SCORPION |
摘要 |
<p>The invention provides a peptide capable of blocking voltage-gated K<+> channels and inhibiting IL-2 production, which is represented by an amino acid sequence of: Ala-Ser-Cys-Arg-Thr-Pro-Lys-Asp-Cys-Ala-Asp-Pro-Cys-Arg-Lys- Glu-Thr-Gly-Cys-Pro-Tyr-Gly-Lys-Cys-Met-Asn-Arg-Lys-Cys-Lys- Cys-Asn-Arg-Cys; in which the C-terminal is amidated and four disulfide bridges are present in the molecule, and their related peptides isolated from the venom gland of a scorpion Heterometrus spinnifer. The peptides provided by the present invention are neuropeptides which can block voltage-gated K<+> channels and inhibit IL-2 production at an extremely low concentration and, therefore, are expected to contribute to application of scorpion toxins to medicines and so on. <IMAGE></p> |
申请公布号 |
EP0916681(A1) |
申请公布日期 |
1999.05.19 |
申请号 |
EP19970950385 |
申请日期 |
1997.12.25 |
申请人 |
SUNTORY LIMITED |
发明人 |
LEBRUN, BRUNO;ROMI-LEBRUN, REGINE;MINAKATA, HIROYUKI;NAKAJIMA, TERUMI;HASHINO, JUNKO |
分类号 |
A61K38/00;C07K14/435;(IPC1-7):C07K14/435;A61K38/17 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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