| 摘要 |
<p>The inventor provides suppositories comprising as the active ingredient 6-amino-5-chloro-1-isopropyl-2-(4-methyl-1 -piperazinyl) benzimidazole (I). These suppositories are expected to exert drug effects based on serotonin3 antagonistic activity when administered rectally. More particularly, these suppositories are useful as antiemetic agents for vomiting accompanying chemotherapy for cancer or remedies for irritable bowel syndrome based on the serotonin3 antagonistic activity. These suppositories provide also excellent storage stability of benzimidazole derivative (I). <CHEM></p> |
