SOLID FORMULATION BLENDED WITH SLIGHTLY WATER SOLUBLE INGREDIENT

摘要

PROBLEM TO BE SOLVED: To homogeneously and stably blend a slightly water soluble medicinal agent in a solid formulation. SOLUTION: This solid formulation blended with a slightly water soluble ingredient is obtained by homogeneously blending a slightly water soluble ingredient having <=1 mg/ml solubility in water in a formulation using a suspension liquid suspended in a mixture of a water soluble excipient with water as a binder by a wet granulation method. The water soluble excipient is at least one selected from water soluble polymers and water soluble sugars and the number average particle size of the slightly water soluble ingredient is <=20μm.