| 摘要 |
(9 alpha , 13 alpha ,14 alpha )-1-(3-Methoxymorphinan-17-yl)alkanones of the formula wherein R signifies lower alkanoyl, are valuable intermediates for the manufacture of dextromethorphan of the formula They can be produced in an advantageous manner by cyclization of a (R)- or (S)-1-[1-(4-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydro-isoquinolin-2-yl]alkanone of the formula with an alkylsulfonic acid or a mixture of alkylsulfonic acids at a temperature between about 5 DEG and 50 DEG C., but above the melting point of the alkylsulfonic acid used or of the alkylsulfonic acid mixture used, and can be converted into dextromethorphan in a manner known per se by cleavage or the residue R and N-methylation.
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