| 摘要 |
PROBLEM TO BE SOLVED: To provide the subject novel substance that is obtained from a microorganism in Streptomyces capable of producing a physiologically active substances NK3042A and NK3024B, has the TNFαproduction inhibitory action and is useful for treatment and prevention of rheumatoid arthritis, Kawasaki disease, cancer cachexia, and the like. SOLUTION: This novel substances have the following physical and chemical properties: appearance, white powder; melting point, 129-131 deg.C (decomposition); molecular formula, C30 H46 N2 O10 S; Molecular weight, 626; solubility, readily soluble in water, methanol and dimethyl sulfoxide; soluble in methanol; insoluble in n-hexane and ethyl acetate; the color reactions, positive to Rydon-Smith, ninhydrin, sulfuric acid and potassium permanganate; negative to Ehrlich, Skaguchi, and Dragendorff; the Rf value, 0.5 according to the silica gel thin layer chromatography with an eluent solvent of l-butanol-acetic acid-water (4:1:1). These compounds, NK30424 A or B (or their salts) are useful for treatment and prevention of rheumatoid arthritis, Kawasaki disease, Crohn disease, Behcet's disease, bronchial asthma, cancer cachexia, septicemia, multiple sclerosis, and dementia. |
