Human nip-45: interleukin-4 gene transcriptional trans-activator and its uses

摘要

A human NIP45 polypeptide is described which trans-activates transcription of the human IL-4 gene. A full length cDNA which encodes the novel trans-activator polypeptide is disclosed as well as the interior structural region and the amino acid residue sequence of the human NIP45. Methods are provided to identify compounds that modulate the biological activity of the native IL-4 transcription associated biomolecule and hence regulate IL-4 transcription.