Detection of neurodegenerative diseases

摘要

The present invention provides methods for determining whether an individual is predisposed to Alzheimer's disease or other neurodegenerative disease in a human. Nucleic acid molecules are also provided which have a polymorphism which is associated with a predisposition or reduced risk for Alzheimer's disease or another neurodegenerative disease. The present invention further provides kits which can be used to detect the presence of polymorphisms associated with Alzheimer's disease or neurodegenerative disorders. The present invention also provides antibodies which preferentially recognizes a variant form of a Krebs tricarboxylic acid cycle component protein which is encoded by a gene consisting of a polymorphism and methods of using the antibodies, wherein the presence of said variant form is indicative of a predisposition or reduced risk for Alzheimer's disease or other neurodegenerative diseases.