METHODS OF IDENTIFYING AND DIAGNOSING INFLAMMATORY BOWEL DISEASE OR SUBTYPES WITH THE NRAMP LOCUS

摘要

Methods of identifying, diagnosing and screening for inflammatory bowel disease (IBD), particularly ulcerative colitis (UC), Crohn's disease and their subtypes, comprise identifying alleles and polymorphisms associated with a biological response related to an inflammatory bowel disease, such as UC. A method determines whether a therapy which alters the level or functionality of NRAMP is effective in treating an inflammatory bowel disease, UC, CD or their subtypes. A kit for screening for susceptibility to inflammatory bowel diseases comprises DNA from the functional (structural gene) or satellite regions of the NRAMP locus, oligonucleotides thereof or antisense nucleic acids thereto.