The invention is directed to polynucleotides encoding all or a fragment of the P450 moiety of vitamin D 1- alpha -Hydroxylase and polypeptides encoded thereby. It encompasses antibodies to the polynucleotides and hybridizing polynucleotides. The polynucleotides and polypeptides are used in methods of diagnosing and treating vitamin D-related disorders and of producing vitamin D metabolites. The invention also encompasses expression vectors and animal cells comprising the polynucleotides.
申请公布号
WO9907835(A3)
申请公布日期
1999.05.14
申请号
WO1998CA00758
申请日期
1998.08.06
申请人
SHRINERS HOSPITALS FOR CHILDREN;ST-ARNAUD, RENE;GLORIEUX, FRANCIS, H.