Tumor-suppressing protein conductin

摘要

The protein conductin (I) and its variants, mutants and fragments are new. Independent claims are also included for the following: (1) composition for diagnosing tumors comprising an agent that detects (I), the (I)-encoding gene (II) or derived mRNA; (2) composition for treating tumors containing an agent that activates or reactivates (I) in vivo; (3) cDNA (III) that encodes (I), its variants, mutants or fragments; (4) use of (II) for gene therapy of tumors; and (5) partial sequences of the adenomatosis polyposis coli (APC) protein comprising amino acids (aa) 1464-1604, 1516-1595, 1690-1778 or 1995-2083 as RGS-domain interaction sites (RGS = regulator of G-protein signaling).