NOVEL PROCESS FOR THE PREPARATION OF CEPHALOSPORINS USING -i(ACREMONIUM CHRYSOGENUM)

摘要

An improved process for production of an N-acylated cephalosporin is described. The process utilizes an Acremonium strain which has been modified to express an acyl transferase of a filamentous fungus and is selected for production of the N-acylated cephalosporin at a level which is equal to or higher than the production of the corresponding alpha-aminoadipyl-7-cephalosporins in the strain.