N,N-DIMETHYL-2-[5-(1,2,4-TRIAZOLE-1-YL-METHYL)-1H-INDOLE-3-YL]-ETHYLAMINE SULFATE SALT (2:1) AND ITS PHARMACEUTICALLY ACCEPTABLE HYDRATES, METHODS OF ITS PREPARING, A PHARMACEUTICAL COMPOSITION ON ITS BASE, A METHOD OF ITS PREPARING AND A DRUG

摘要

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to a new compound - N,N-dimethyl-2-[5-(1,2,4-triazole-1-yl-methyl)-1H-indole-3-yl]-ethylamine sulfate salt (2:1) of structural formula (I) and its pharmaceutically acceptable hydrate. Method of producing salt or its hydrate involves an interaction of N,N-dimethyl-2-[5-(1,2,4-triazole-1-yl-methyl)-1H-indole-3-yl]-ethylamine of the formula (II) with about 0.5 molar equivalent sulfuric acid in a suitable solvent. Invention describes a pharmaceutical composition and a drug for treatment and/or prophylaxis of clinical states where the use of a selective agonist of 5-HT1-like receptors is indicated. N, N-Dimethyl-2-[5-(1,2,4-triazole-1-yl-methyl)-1H-indole-3-yl] -ethylamine sulfate salt is a selective agonist of 5-HT1-like receptors and therefore is benefit for treatment of patients with clinical disorders, especially migraine and related disorders, where the use of a selective agonist of these receptors is indicated. EFFECT: improved method of preparing, enhanced effectiveness of a drug proposed. 17 cl, 17 ex