| 摘要 |
<p>This invention takes advantage of the finding that neurite outgrowth and nerve regeneration are promoted by disruption of the steroid receptor complex. This disruption can take the form of disruption of the physical assembly or function of the steroid receptor complex, such as the mature complex or a precursor of the mature complex that is required for assembly of the mature complex. Geldanamycin and its analogs, as well as FKBP-52 antibody, are shown to disrupt the complex and promote nerve growth. In addition to these compounds, the invention includes assays for finding neurotrophic compounds, as well as compounds found by these assays, pharmaceutical compositions into which they are incorporated, and methods of treating subjects having neuronal dysfunction caused by injury or disease.</p> |
