发明名称 |
Improved riboflavin production |
摘要 |
The present invention is directed to a recombinant bacterium comprising a bacterium which has been transformed by three vectors, two of them each comprising a DNA sequence coding for the riboflavin synthesizing enzymatic activities of Bacillus subtilis or a DNA sequence which is substantially homologous and one or more transcription elements and a third vector comprising a DNA sequence coding for the ribA gene product of Bacillus subtilis or a DNA sequence which is substantially homologous and optionally further comprising a transcription element whereby one or a plurality of copies of each of these vectors has/have been integrated at three different sites within its chromosome; and a process for the production of riboflavin by such a recombinant bacterium. |
申请公布号 |
EP0821063(A3) |
申请公布日期 |
1999.05.06 |
申请号 |
EP19970111984 |
申请日期 |
1997.07.15 |
申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
HOHMANN, HANS-PETER;HUEMBELIN, MARKUS;VAN LOON, ADOLPHUS;SCHURTER, WALTER |
分类号 |
A23K1/16;A23L1/30;C07H21/04;C12N1/21;C12N15/00;C12N15/09;C12N15/52;C12P25/00;C12R1/125;(IPC1-7):C12N15/52;A23L1/302 |
主分类号 |
A23K1/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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