发明名称 |
NEW BIS-PLATINUM COMPLEXES WITH POLYAMINE LIGANDS AS ANTITUMOR AGENTS |
摘要 |
<p>PCT No. PCT/US97/12553 Sec. 371 Date Feb. 16, 1999 Sec. 102(e) Date Feb. 16, 1999 PCT Filed Jul. 22, 1997 PCT Pub. No. WO98/03519 PCT Pub. Date Jan. 29, 1999Bis-platinum(II) complexes with polyamine ligands, including spermidine and spermine, are disclosed. The method of making the bis-platinum(II) complexes, using a DMF complex, and the use of the bis-platinum complexes for the treatment of tumors in mammals are also disclosed. The method of making the polyamine ligands and the use of a new polyamine compound as an intermediate in the synthesis of polyamine ligands are also disclosed.</p> |
申请公布号 |
EP0912584(A2) |
申请公布日期 |
1999.05.06 |
申请号 |
EP19970933548 |
申请日期 |
1997.07.22 |
申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
FARRELL, NICHOLAS, P.;MENTA, ERNESTO;DI DOMENICO, ROBERTO;SPINELLI, SILVANO |
分类号 |
A61P35/00;A61K31/282;C07C209/50;C07C211/09;C07C211/14;C07C237/10;C07C269/04;C07C271/16;C07F15/00;(IPC1-7):C07F15/00;A61K31/28;C07C269/06 |
主分类号 |
A61P35/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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