POLYMERIC SYSTEMS FOR DRUG DELIVERY AND USES THEREOF
摘要
Biodegradable polymeric implants can provide a safe and efficient means to deliver drugs in the treatment of various diseases. Although a polymeric drug delivery system can be implanted as a solid device within a subject, it is also possible to administer such a system as an injectable liquid which solidifies in vivo. An improved formulation of a polymeric drug delivery system comprises a water insoluble copolymer that is a solid or wax at 37 DEG C, a water soluble polymer that is a liquid at 25 DEG C, and a hydrophobic drug. These drug delivery systems can be administered by injection, and do not require the use of a toxic curing agent or inconvenient temperature manipulations.
申请公布号
WO9921908(A1)
申请公布日期
1999.05.06
申请号
WO1998CA00994
申请日期
1998.10.29
申请人
ANGIOTECH PHARMACEUTICALS, INC.;UNIVERSITY OF BRITISH COLUMBIA;JACKSON, JOHN;ZHANG, XICHEN;BURT, HELEN, M.