发明名称 |
INDUCIBLE CELLULAR IMMUNITY THROUGH ACTIVATION OF TH1 AND SUPPRESSION OF TH2 RESPONSES BY MACROPHAGES |
摘要 |
The present invention relates to the use of macrophages in the function of antigen presenting cells (APC) to redirect the balance of the CD4+ T helper 1 (Th1)/CD4+ T helper 2(Th2) cell subsets during an immune response. More particularly, the present invention is directed to pharmaceutical formulations comprising macrophages or a cell population containing macrophages, optionally together with a suitable excipient, and methods for suppressing the Th2 dependent humoral immune response and/or to stimulate the Th1 dependent, cellular immune response.
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申请公布号 |
CA2307343(A1) |
申请公布日期 |
1999.05.06 |
申请号 |
CA19982307343 |
申请日期 |
1998.10.22 |
申请人 |
VLAAMS INTERUNIVERSITAIR INSTITUUT VOOR BIOTECHNOLOGIE VZW |
发明人 |
FIERS, WALTER;DESMEDT, MARJORY;GROOTEN, JOHAN |
分类号 |
A61K35/12;A61K38/00;C12N5/0786;C12N5/10;(IPC1-7):C12N5/10 |
主分类号 |
A61K35/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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