MULTI-WELL SINGLE-MEMBRANE PERMEATION DEVICE AND METHODS

摘要

The invention provides exemplary testing devices, systems and methods for evaluating the permeation of various chemicals through different types of cells. In one exemplary embodiment, a testing device (100) is provided which comprises a base member (102) and a top member (104) having a plurality of wells (110) which are aligned when the top member (104) is secured to the base member (102). A membrane sheet (106) which includes at least one layer of cells grown on the sheet (106) is placed between the base member (102) and the top member (104) prior to assembly. Test samples are placed into the wells (110) in the top member (104) and samples are removed from the top and bottom wells (110) at a later time and tested to determine the amount of test sample which permeated through the cells.