A proces for the synthesis of 1-(4-Arylpiperazine-1-y1)-3-(2-oxypyrrolidin/piperidin-1-yl)propanes as therapeutic agents for hypertension, ischemia, cardiovascular and other adrenergic receptors related disorders

摘要

A process of preparing novel compounds of formula 1 Wherein Ar represents a phenyl ring substituted by the groups like halo, alkoxy, alkyl or heteroaryl, n=1 or n=2; said compounds are used as potential therapeutic agents for hypertension, ischemic, cardiovascular and other adrenergic receptors related disorders, said process comprising condensing 2-pyrrolidone of formula 2 (n=1) or 2-piperidone of formula 2 (n=2) with 1-Ä4-substituted arylpiperazin-1-ylÜ-3-chloropropanes of formula 5 where Ar represents a phenyl ring substituted by the groups like halo, alkoxy, alkyl or heteroaryl in the presence of a base and organic solvent at a temperature ranging from 120-150 DEG C for a period varying between 90 min. to 14 hrs. to produce the corresponding 1-Ä4-substituted arylpiperazin-1-ylÜ-3-Ä2-oxopyrrolidin/piperidin-1-ylÜpropanes of formula 1.