Catalytic antibodies which hydrolyze primary amides and methods for eliciting such antibodies

摘要

PCT No. PCT/US94/04437 Sec. 371 Date May 4, 1996 Sec. 102(e) Date May 4, 1996 PCT Filed Apr. 22, 1994 PCT Pub. No. WO94/25573 PCT Pub. Date Nov. 10, 1994Described and claimed are compounds of formula (I) wherein Y is a polypeptide, R1 is bonded to the N-terminus of Y and is hydrogen or a branched or linear, substituted or unsubstituted, C1-21 alkyl, alkene, or alkyne group, R2 is a side chain of a naturally occurring amino acid, and X is (a), (b), (c). Such compounds are useful as haptens and immunogens for the elicitation of antibodies which catalytically enhance the rate of formation or hydrolysis of primary amide bonds. Also described and claimed are methods employing the compounds and antibodies.