发明名称 |
Metal complexed serine protease inhibitors |
摘要 |
Serine protease inhibitors are provided comprising compounds having a P site binding moiety and a divalent cation(s) chelating moiety which are pre-prepared as divalent cation(s) complexes or combined with the serine protease in the presence of divalent cation(s). The compounds are shown to have high inhibitory activity when complexed to divalent cation(s) and find use in various processes associated with serine protease isolation and inhibition.
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申请公布号 |
US5900371(A) |
申请公布日期 |
1999.05.04 |
申请号 |
US19970925844 |
申请日期 |
1997.09.08 |
申请人 |
AXYS PHARMACEUTICALS INC.;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
CLARK, JAMES M.;JENKINS, THOMAS E.;KATZ, BRADLEY A.;STROUD, ROBERT M. |
分类号 |
C07K14/81;C12N9/64;(IPC1-7):C12N9/76;C12N11/08;C12N9/99 |
主分类号 |
C07K14/81 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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