| 摘要 |
A controlled release formulation for use with a variety of drugs, vaccines or hormones are formed in microspherical form. The drug, vaccine or hormone, e.g. bovine somatropine, hepatitis vaccine, is suspended in a polymer matrix. The polymer matrix is formed from at least two water soluble biodegradable polymers, selected for example from starch, crosslinked starch, ficoll, polysucrose, polyvinyl alcohol, gelatine, hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl-ethyl cellulose, hydroxypropyl-methyl cellulose, sodium carboxymethyl cellulose, cellulose acetate, sodium alginate, polymaleic anhydride esters, polyortho esters, polyethyleneimine, polyethylene glycol, methoxypolyethylene glycol, ethoxypolyethylene glycol, polyethylene oxide, poly(1,3 bis(pcarboxyphenoxy) propane-co-sebacic anhydride, N,N-diethylaminoacetate, block copolymers of polyoxyethylene and polyoxypropylene, The microspheres are coated with a (d,l lactide-glycolide) copolymer. The coating makes the microspheres more resistant to enzymatic degradation.
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