发明名称 |
Viral clearance process |
摘要 |
Methods for producing immunoglobulins and in particular anti-D immunoglobulin substantially free of virus and product resulting therefrom. Specifically provided are methods for nanofiltration of the anti-D immunoglobulin in high ionic strength buffer and with excipient such as polysorbate 80. Additional steps include diafiltration to concentrate the anti-D protein and reduce the concentration of excipient present. |
申请公布号 |
AU1081799(A) |
申请公布日期 |
1999.05.03 |
申请号 |
AU19990010817 |
申请日期 |
1998.10.14 |
申请人 |
ORTHO DIAGNOSTIC SYSTEMS INC.;MILLIPORE CORPORATION |
发明人 |
ROBERT WILLIAM VAN HOLTEN;GILBERT J. QUINTON;GEORGE E. OULUNDSEN JR. |
分类号 |
A61K39/395;A61L2/00;A61P37/02;C07K1/34;C07K16/00;C07K16/06;C07K16/34 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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