发明名称 ANTI-IDIOTYPE MONOCLONAL ANTIBODIES, THEIR USE IN ACTIVE IMMUNOTHERAPY OF MALIGNANT TUMORS AND COMPOSITIONS CONTAINING THEM
摘要 <p>Monoclonal anti-idiotype antibody which is specific for murine antibodies against gangliosides carrying N-glycolylated sialic acid particularly against those gangliosides which are expressed by tumoral cells. The monoclonal antibody is useful as immunomodulator for the treatment of cancer. Specifically, the monoclonal anti-idiotype antibody of the present invention is capable of inducing a response which is predominantly anti-idiotypic in xenogenic models. The monoclonal anti-idiotype antibody also exerts a protector effect against malignant tumors in animals</p>
申请公布号 WO1999020656(A1) 申请公布日期 1999.04.29
申请号 CU1998000007 申请日期 1998.10.21
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