| 摘要 |
<p>Synthetic cell membranes which are bonded to a noble metal support and which comprise novel spacer peptides of formula (I) are disclosed. These membranes can incorporate membrane proteins and can be used in biosensing devices. Peptides or peptide-analogous compounds of the formula (I) are disclosed, X-L?N-AN-B-AC-LC¿-Y in which preferred embodiments have the following meaning: a) group X contains at least one sulphur atom, e.g. group X represents a Lip group or a group like HS-(CH¿2?)2-CO-; groups A?N and LN¿ both represent single bonds; group AC represents Pro Xaa1 Xaa1; group LC represents a single bond or an oligomer (number of monomers between 2 and 4) of a medium chain φ-amino acid like 6-aminocaproic acid; group Y represents Lys(Myr)-Lys(Myr), where Myr represents a myristoyl residue bound to the side chain amino group of Lys; or b) group X represents Myr-Lys(Myr), where Myr represents myristoyl residues bound to the amino groups of Lys; group LN represents a single bond or an oligomer (number of monomers between 2 and 4) of a medium chain φ-amino acid like 6-aminocaproic acid; groups AN represents Pro Xaa1 Xaa1; groups A?C and LC¿ both represent single bonds; group Y contains at least one sulphur atom, e.g. group Y represents Cys-amide or group like -NH-(CH¿2?)2-SH.</p> |
