发明名称 |
New epothilone derivatives |
摘要 |
Epothilone derivatives (I) are new. They are prepared from a number of new and known starting compounds. Epothilone derivatives of formula (I) are new. R<1>a, R<1>b = H, 1-10C alkyl, aryl, 7-20C aralkyl or together form (CH2)m; m = 2-5; R<2>a, R<2>b = have the same meanings as R<1>a and R<1>b, provided that when D-E is CH2-CH2 or Y is O, then R<2>a and R<2>b are not H or CH3; R<3>, R<5> = H, 1-10C alkyl, aryl or 7-20C aralkyl; R<4>a, R<4>b have the same meanings as R<1>a, R<1>b or R<2>a, R<2>b; D-E = CH2-CH2, CH=CH, C?=C, epoxy, CH(OH)-CH(OH) or CH(OH)-CH2; R<6>, R<7> = H, or together form a bond or an O atom; R<8> = H, 1-10C alkyl, aryl or 7-20C aralkyl, which are all optionally substituted; X = O, two OR<23> groups, a 2-10C alkylene- alpha , w-dioxy group, H/OR<9> or CR<10>R<11>; R<23> = 1-20C alkyl; R<9> = H or a protecting group; R<10>, R<11> = H, 1-10C alkyl, aryl or 7-20C aralkyl, or together form a 5-7 membered carbocycle; Y = one O or two H atoms; Z = one O atom or H/OR<12>; and R<12> = H or a protecting group.
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申请公布号 |
DE19748928(A1) |
申请公布日期 |
1999.04.29 |
申请号 |
DE1997148928 |
申请日期 |
1997.10.24 |
申请人 |
SCHERING AG, 13353 BERLIN, DE |
发明人 |
KLAR, ULRICH, DR., 13503 BERLIN, DE;SCHWEDE, WOLFGANG, DR., 13467 BERLIN, DE;SKUBALLA, WERNER, DR., 13465 BERLIN, DE;BUCHMANN, BERND, DR., 16540 HOHEN NEUENDORF, DE;SCHIRNER, MICHAEL, DR., 13156 BERLIN, DE |
分类号 |
C07C45/29;C07C45/56;C07C45/67;C07C49/185;C07C49/337;C07C49/355;C07C59/185;C07D213/50;C07D213/55;C07D263/22;C07D277/22;C07D277/24;C07D307/33;C07D309/12;C07D319/06;C07D319/14;C07D405/06;C07D405/12;C07D405/14;C07D407/04;C07D407/12;C07D417/06;C07D417/12;C07D417/14;C07D493/04;C07F7/18;(IPC1-7):C07F7/18;C07B51/00;C07F9/547;C07B57/00;C07F9/54;C07D307/30;C07D213/24 |
主分类号 |
C07C45/29 |
代理机构 |
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代理人 |
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