HIGH EXPRESSION MODULES CONTAINING TWO OR MORE TANDEM COPIES OF A METHIONINASE ENCODING SEQUENCE

摘要

The construction of multicopy expression systems for methioninase are disclosed. The higher expression systems employ a promoter operably linked to two or more copies of a tandemly repeated methioninase encoding sequence. Such multicopy expression systems were found to produce unexpectedly high levels of methioninase when expressed in an appropriate host.