| 摘要 |
<p>The invention provides estrogens and antiestrogens of formula (I) having structure (I) wherein R is (II), (III), (IV), or (V); R?1 and R2¿ are each, independently, alkyl of 1-6 carbon atoms, or are alkyl groups which are taken together to form a 5-7 membered satured heterocycle; X is hydroxy, alkoxy of 1-6 carbon atoms, or -OC(O)R3; W is (VI), hydroxy, alkyl of 1-6 carbon atoms, halogen, -CF¿3?, alkoxy of 1-6 carbon atoms, -CHO, cyano, alkylcarbonyl of 2-7 carbon atoms, alkoxycarbonyl of 2-7 carbon atoms, amino, alkylamino of 1-6 carbon atoms, dialkylamino of 1-6 carbon atoms per alkyl group, trifluoromethoxy, hydroxyalkyl of 1-6 carbon atoms, alkoxyalkyl of 2-12 carbon atoms, -CN, -SO3H, or -CO2H; R?3¿ is alkyl of 1-6 carbon atoms; Z is (VII), (VIII), (IX), or (X); Y is (XI), (XII), or (XIII); R4 is hydrogen, alkyl of 1-6 carbon atoms, alkoyl of 2-7 carbon atoms, or benzoyl; Q is hydrogen, -OR5, or -NR6R7; R5 is hydrogen or alkyl of 1-6 carbon atoms; R?6 and R7¿ are each, independently, alkyl of 1-6 carbon atoms, or are alkyl groups which are taken together to form a 5-7 membered saturated heterocycle; n = 4-12; and p = 2-6; or a pharmaceutically acceptable salt thereof.</p> |
