发明名称 |
DNA ENCODING A GABABR2 POLYPEPTIDE AND USES THEREOF |
摘要 |
This invention provides isolated nucleic acids encoding a mammalian GABABR2 polypeptide, an isolated GABABR2 protein, vectors comprising isolated nucleic acid encoding mammalian GABABR2 polypeptides, cells expressing mammalian GABABR1/R2 receptors, antibodies directed to an epitope on mammalian GABABR2 polypetides or mammalian GABABR1/R2 receptors, nucleic acid probes useful for detecting nucleic acids encoding mammalian GABABR2 polypeptides, antisense oligonucleotides complementary to unique sequences of nucleic acids encoding mammalian GABABR2 polypeptides, nonhuman transgenic animals which express DNA encoding normal or mutant mammalian GABABR1/R2 receptors, as well as methods of screening compounds acting as agonists or antagonists of mammalian GABABR1/R2 receptors.
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申请公布号 |
WO9920751(A1) |
申请公布日期 |
1999.04.29 |
申请号 |
WO1998US22033 |
申请日期 |
1998.10.16 |
申请人 |
SYNAPTIC PHARMACEUTICAL CORPORATION;JONES, KENNETH, A.;LAZ, THOMAS, M.;BOROWSKY, BETH |
发明人 |
JONES, KENNETH, A.;LAZ, THOMAS, M.;BOROWSKY, BETH |
分类号 |
A61K38/00;C07K14/705;(IPC1-7):C12N15/10;C12N15/12;C12N5/10;C12Q1/68 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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