| 发明名称 |
LOW-TOXICITY HUMAN INTERFERON-ALPHA ANALOG |
| 摘要 |
The present invention describes a method of reducing the cytotoxicity of interferon-alpha by making defined amino acid substitutions in the N-terminal portion of the polypeptide sequence. Also described are human interferon-alpha analogs with low cytotoxicity, and therapeutic applications of the low-toxicity interferon-alpha analogs.
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| 申请公布号 |
WO9920653(A1) |
申请公布日期 |
1999.04.29 |
| 申请号 |
WO1998US21936 |
申请日期 |
1998.10.20 |
| 申请人 |
PEPGEN CORPORATION;UNIVERSITY OF FLORIDA |
发明人 |
JOHNSON, HOWARD, M.;PONTZER, CAROL, H.;VILLARETE, LORELIE, H.;CAMPOS, JACKELINE |
| 分类号 |
A61K38/21;A61K31/00;A61K38/00;A61P29/00;A61P31/00;A61P31/12;A61P35/00;A61P37/00;A61P37/02;A61P37/06;C07K14/19;C07K14/555;C07K14/56;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12N15/20;C12N15/21;C12N15/62;(IPC1-7):C07K14/56 |
主分类号 |
A61K38/21 |
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