发明名称 |
CYCLOHEXANE DERIVATIVES DIFUNCTIONALISED IN 1,4 AS LIGANDS OF 5T H1A RECEPTORS |
摘要 |
The invention concerns novel cyclohexane derivatives difunctionalised in 1,4 of general formula (I) in which A represents a group such as (IIa) in which Ar itself represents an aromatic structure such as phenyl or pyrimidinyl optionally substituted by one or several groups such as C1-C3 alkyl, C1-C3 alkoxy, trifluoromethyl or halogen (IIb); B represents a heterocyclic group such as: 3,5-dioxo-(2H,4H)-1,2,4 triazine substituted in position 2 (IIIa); 3-oxo-(2H)-1,2,4 triazine substituted in position 5 (IIIb); 3,5-dioxo-6-amino-(2H,4H)-1,2,4-triazine (IIIc) in which R represents a C1-C3 alkyl group. The invention also concerns the salts of compounds of general formula I with pharmaceutically acceptable acids. It also concerns the various "cis" and "trans" isomers and the various enantiomers with asymmetric carbons.
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申请公布号 |
WO9920613(A1) |
申请公布日期 |
1999.04.29 |
申请号 |
WO1998FR02207 |
申请日期 |
1998.10.14 |
申请人 |
PIERRE FABRE MEDICAMENT;PATOISEAU, JEAN-FRANCOIS;DUPONT-PASSELAIGUE, ELISABETH;KOEK, WOUTER |
发明人 |
PATOISEAU, JEAN-FRANCOIS;DUPONT-PASSELAIGUE, ELISABETH;KOEK, WOUTER |
分类号 |
C07D253/06;A61K31/53;A61P1/04;A61P3/04;A61P9/10;A61P9/12;A61P25/04;A61P25/06;A61P25/18;A61P25/20;A61P25/22;A61P25/24;A61P25/28;A61P43/00;C07D253/075;C07D403/12;C07D405/12;(IPC1-7):C07D253/06 |
主分类号 |
C07D253/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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