SPACER PEPTIDES AND MEMBRANES CONTAINING SAME

摘要

Synthetic cell membranes which are bonded to a noble metal support and which comprise novel spacer peptides of formula (I) are disclosed. These membranes can incorporate membrane proteins and can be used in biosensing devices. Peptides or peptide-analogous compounds of the formula (I) are disclosed, X-L-A-B-A-L-Y in which preferred embodiments have the following meaning: a) group X contains at least one sulphur atom, e.g. group X represents a Lip group or a group like HS-(CH2)2-CO-; groups A and L both represent single bonds; group A represents Pro Xaa<1> Xaa<1>; group L represents a single bond or an oligomer (number of monomers between 2 and 4) of a medium chain omega -amino acid like 6-aminocaproic acid; group Y represents Lys(Myr)-Lys(Myr), where Myr represents a myristoyl residue bound to the side chain amino group of Lys; or b) group X represents Myr-Lys(Myr), where Myr represents myristoyl residues bound to the amino groups of Lys; group L represents a single bond or an oligomer (number of monomers between 2 and 4) of a medium chain omega -amino acid like 6-aminocaproic acid; groups A represents Pro Xaa<1> Xaa<1>; groups A and L both represent single bonds; group Y contains at least one sulphur atom, e.g. group Y represents Cys-amide or group like -NH-(CH2)2-SH.