ENHANCER TOLERANT PRESSURE SENSITIVE ADHESIVE COMPOSITION FOR TRANSDERMAL DRUG DELIVERY

摘要

Pressure sensitive adhesive compositions for use in transdermal drug delivery systems comprising an adhesive composition which is tolerant to plasticization by cutaneous penetration enhancers contained in the transdermal drug formulation are disclosed. Specifically, the pressure sensitive adhesive composition of the present invention comprises an acrylic copolymer prepared from (i) at least 40% by weight of th total monomer composition of alkyl acrylate monomers with a Tg of -90 to 0.degree.C, (ii) 0-15 % by weight of the total monomer composition of monomers with a Tg of 0 to 250.degree.C, and (iii) 10-60% by weight of the total monomer composition of substituted acrylamides or methacrylamides having the structural formula: (see fig. I) wherein R1 is H or CH3, R2 is H or CH3, and R3 is (a) CH3, (b) C(CH3)2-(CH2)n-CH3 where n is 0 through 17, or (c) substituents of the formula: (see fig. II) where m is 0 through 10, and optionally (iv) at least 0.2% by weight of acrylic monomers containing at least one group having a reactive hydrogen, and (v) 0.01-2% by weight of a chelated metal alkoxide crosslinker to (i), (ii) and (iii).