发明名称 |
Humanized anti-CD11a antibodies |
摘要 |
Humanized anti-CD11a antibodies and various uses therefor are disclosed. The humanized anti-CD11a antibody may bind specifically to human CD11a I-domain, have an IC50(nM) value of no more than about 1nM for preventing adhesion of Jurkat cells to normal human epidermal keratinocytes expressing ICAM-1, and/or an IC50 (nM) value of no more than about 1nM in the mixed lymphocyte response assay. |
申请公布号 |
ZA9709599(B) |
申请公布日期 |
1999.04.28 |
申请号 |
ZA19970009599 |
申请日期 |
1997.10.27 |
申请人 |
GENENTECH, INC. |
发明人 |
PAULA M. JARDIEU;LEONARD G. PRESTA |
分类号 |
G01N33/53;A61K38/00;C07K16/28;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12P21/08 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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