| 发明名称 |
Protein kinases as tools for the diagnosis and treatment of Alzheimer's disease |
| 摘要 |
<p>The invention relates to protein kinases which are responsible for the conversion of the amino acids of the tau protein giving rise to specifically phosphorylated tau epitopes, and to antibodies specific for said protein kinases. The invention further relates to pharmaceutical compositions for the treatment of Alzheimer's disease and to diagnostic compositions for the diagnosis of Alzheimer's disease. Furthermore, the invention relates to methods for the detection and/or monitoring of Alzheimer's disease and to methods for the in vitro diagnosis and/or monitoring of Alzheimer's disease and/or the in vitro conversion of tau protein to Alzheimer tau protein.</p> |
| 申请公布号 |
EP0911390(A2) |
申请公布日期 |
1999.04.28 |
| 申请号 |
EP19980121176 |
申请日期 |
1992.12.07 |
| 申请人 |
MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. |
发明人 |
MANDELKOW, EVA-MARIA;MANDELKOW, ECKHARD;DREWES, GERARD;BIERNAT, JACEK;LICHENBERG-KRAAG, BIRGIT;STEINER, BARBARA |
| 分类号 |
C12N15/02;A61K38/00;A61K38/45;A61K38/46;A61K38/55;A61K39/00;A61K39/395;A61P25/28;C07K1/18;C07K7/06;C07K7/08;C07K14/47;C07K14/81;C07K16/00;C07K16/18;C07K16/40;C12N5/10;C12N9/12;C12N9/16;C12N15/09;C12N15/12;C12N15/16;C12P21/02;C12P21/08;C12Q1/68;G01N33/50;G01N33/53;G01N33/573;G01N33/68;(IPC1-7):C12N9/12 |
主分类号 |
C12N15/02 |
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