| 摘要 |
<p>The present invention provides a quinolinomorphinan derivative or a pharmacologically acceptable acid addition salt thereof, and an agent for curing . preventing cerebral disorders composed of the derivative and salt thereof, which is represented by the following formula (I): <CHEM> Äwherein R<1> represents cyclopropylmethyl or the like; R<2> and R<3> independently represent hydroxy, methoxy, or the like; R<4> represents hydrogen, methyl, amino, or the like; and (R<5>)m represents hydrogen, substituted benzo, or the likeÜ. The compounds of the present invention have the excellent effect of preventing damages of the cerebral nerve cells. Therefore, the compounds of the present invention are useful as medicines used for curing . preventing various cerebral diseases such as cerebral stroke, traumatic cerebral diseases, cerebral edema, and cerebral neurodegenerative diseases, ameliorating aftereffects thereof, and preventing the recurrence thereof by inhibiting various ischemic, hemorrhagic or traumatic cerebral disorders, and damages of the cerebral nerve cells caused by various nerve degenerations.</p> |
