发明名称 |
PYRROLO[2,3-D]PYRIDAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
摘要 |
Pyrrolopyridazine derivatives having the general formula. <CHEM> ÄIn the above formula, R<1> represents a C2-C6 alkenyl group, a halogeno-C2-C6-alkenyl group, a C6-C10 aryl-C2-C6-alkenyl group, a C2-C6 alkynyl group, a C3-C7 cycloalkyl group, a C3-C7 cycloalkyl-C1-C6-alkyl group, a C5-C7 cycloalkenyl-C1-C6-alkyl group or a halogeno-C1-C6-alkyl group; R<2> and R<3> are the same or different and each represents a hydrogen atom, a C1-C6 alkyl group or a C6-C10 aryl group; R<4> represents a hydrogen atom or a C1-C6 alkyl group; R<5> represents a C6-C10 aryl group or a 5-10 membered heteroaryl group comtaining heteroatom(s) selected from nitrogen, oxygen and sulfur; A represents a C1-C3 alkylene group; X represents an imino group, an oxygen atom, a sulfur atom or a methylene group; m represents 0 or 1; and n represents 0 or 1Ü or pharmaceutically acceptable salts thereof. <H0> ÄEffectÜ </H0> The pyrrolopyridazine derivatives of the present invention have an excellent gastric secretion inhibiting activity, gastric mucosa protective activity and antibacterial activity against Helicobacter pylori, and are useful as a preventive or therapeutic agent for ulcerous diseases. |
申请公布号 |
HUT77998(A) |
申请公布日期 |
1999.04.28 |
申请号 |
HU19960001967 |
申请日期 |
1995.01.18 |
申请人 |
SANKYO COMPANY,LIMITED;UBE INDUSTRIES,LIMITED |
发明人 |
FUJIHARA,YOSHIMI;FUJIWARA,HIROSHI;ITOH,ETSURO;KIMURA,TOMIO;MATSUNOBU,KEIJI;SHIBAKAWA,NOBUHIKO;TABATA,KEIICHI;YASUDA,HIROSHI |
分类号 |
E04F13/08;A61K31/5025;A61P1/04;C07D487/04;E04F13/073;E04F13/26;E04F19/02 |
主分类号 |
E04F13/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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