发明名称 |
Dipyridoimidazolderivatives useful in treating central nervous system disorders |
摘要 |
This invention relates to a series of substituted 3-oxo-pyrrolo[1,2-a]imidazopyridine derivatives of the formula 1 where X1-X4, R1, R2 and Ar are defined herein. In addition the invention relates to pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention are ligands for the benzodiazepine site on the GABA-A receptor and display anxiolytic and anticonvulsant activity in animal models. |
申请公布号 |
AU1066499(A) |
申请公布日期 |
1999.04.27 |
申请号 |
AU19990010664 |
申请日期 |
1998.10.05 |
申请人 |
ORTHO-MCNEIL PHARMACEUTICAL, INC. |
发明人 |
BRUCE E. MARYANOFF;DAVID MCCOMSEY;JAMES MCNALLY;SAMUEL O. NORTEY;ALLEN B REITZ |
分类号 |
A61K31/4375;A61P25/00;A61P25/08;A61P25/22;C07D471/14 |
主分类号 |
A61K31/4375 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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